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18 Best Isekai Anime Series of 2021 to Watch

seirei gensouki

The Best New Isekai Anime 2021 List – Let’s Rank All the New Isekai Shows!

With this rise in popularity of Isekai anime, it’s hard not to feel excited about the prospects of what we can expect in 2021.

When it comes to the Isekai genre, there is a lot of anime series to choose from. Here are some new brand tv shows and a bunch of 2nd season and 3rd season releases of some other familiar anime series that you should keep on your watch list this year.

So, What Makes an Isekai Anime Series Interesting?

Isekai anime is a subgenre of anime that features stories and worlds unlike our what have seen so far the real life.

In these anime adaptation series the main characters usually gets transported, reincarnated, or resurrected in an alternate world or a game. in which they venture, getting newfound powers, meeting new species, discover new places, and will have to adjust to their new life.

The Isekai genre is known for having lots of action, comedy, supernatural things, beautiful girls, and magic, but often has an overarching story with a moral message.

With no further ado, let the countdown of the best Isekai Anime Series of 2021 Begin!


18. Cheat Pharmacist’s Slow Life: Making a Drugstore in Another World

Best New Isekai Anime 2021

Reiji wakes up in another world where he has gained the ability to produce and distribute medicines. He starts a drugstore with his newfound companion, Noera, and quickly becomes popular due to the quality of his work. There, he tends to the needs of all who visit the shop with potions and the like.

Cheat Pharmacist’s Slow Life is a perfect isekai anime tv show to watch in 2021, where you will enjoy Reiji’s Drugstore days that are slow-paced but often chaotic.


17. Kyuukyoku Shinka shita Full Dive RPG ga Genjitsu yori mo Kusoge Dattara

Best New Isekai Anime 2021

Yuuki Hiroshi is playing a game called Kiwame Quest. But this game is so lifelike; Yuuki can smell, taste, feel everything in the virtual space. This game also has very realistic interactions like when he’s hurt in the game – his physical body gets hurt too.

He finds out that this immersive experience resulted in the same difficulty as his daily life. His best strategy is to try and improve and conquer the game. Even if this means risking dying trying.

Known in English as Full Dive, this is a popular action-isekai anime of 2021, adapted from the manga with the same title that has a huge following in Japan.


16. Urasekai Picnic

otherside picnic

The “Otherworld” is a dangerous realm controlled by dark and strange creatures, many of which threaten humans and pose a threat

To get a better sense of the abandoned yet serene “Otherworld” that can be experienced here, you might explore hidden doors, ancient elevators, or even lengthy halls.

After an encounter with a denizen of the OtherWorld, Sorao Kamikoshi reflects on whether to keep going or give up in life. Meanwhile, Toriko Nishina searches for her friend Satsuki who she believes to be lost.

When these two cross paths, they became best friends, and they seek more Info about this mysterious dimension.

The two main characters in this isekai anime series of 2021 travel between the real world and their Otherworld counterparts, their bodies will get infected and there will be more dangers awaiting them.


15. Isekai Maou to Shoukan Shoujo no Dorei Majutsu Ω

another world animes

in 2021, the hype is real, because finally, we got the chance to follow the story of the Op Diablo once again in this second season of ‘Isekai Maou to Shoukan Shoujo no Dorei Majutsu’ Anime.

The story depicts Diablo as the most powerful player in Cross Reverie, that one should take care of when going up against him. He has access to some of the game’s rarest and most powerful artifacts, that not the most skilled players will be able to win against him.

Suddenly, Our protagonist, Takuma, finds himself transported and reincarnated in a game world. Now, all he thinks about is finding a way back to Earth with the help of two girls who have summoned and bent him with a contract.

As Takuma continues to venture into this fantasy world as an overpowered master of black magic, he starts to feel more confident and apt in his new life.


14. Tenku Shinpan

tenku shinpan

Tenkuu Shinpan is an isekai anime that spans other subgenres, including action, mystery, horror.

Yuri Honjou witnesses a horrifying man’s death and flees the scene. She finds herself too terrified while watching the assassin, so she hides in an abandoned building.

All doors are closed, Yuri Heads to the rooftop, and finds herself at a dead-end, trapped in an area that has no signs of life, and surrounded by high-rise buildings.

Yuri realizes that her brother is also in this strange place and she is now resolved and ready for anything in order to find him.

It takes a little while for Yuri to realize there are more stalkers murderers around. Yuri starts wondering how long they’ll be able to survive this nightmare.


13. Log Horizon: Entaku Houkai

log horizon 3rd season

Welcome again to the third season of the isekai anime ” Log Horizon”, Log Horizon: Entaku Houkai is a 2021 release that continues depicting the story Elder Tale, which is an online RPG that allows players to live out their adventures throughout different worlds. The twelfth expansion package, “Novasphere Pioneers,” wasn’t installed well and 30K Japanese players were stuck inside when it was released.

Among them is the quiet demeanor, grad student Shiroe, who is not very adept at interacting with others. But to survive in a world full of monsters he forms a guild called “Log Horizon” with an eclectic group of other players.


12. I’ve Been Killing Slimes For 300 Years

Best New Isekai Anime 2021

After many years of working as a corporate slave, Azusa Aizawa passed away. She died suddenly and met a ‘goddess’ who gave her immortality. She was then taken to another world to live in peace.

There, she enjoys farming, protecting the nearby village, and killing 25 slimes per/day., a routine that continues for at least three centuries.

Suddenly she found herself At level 99, and rumors of her power spread throughout the continent. Soon enough, various people show up at her doorstep. Some come seeking a battle, while others come seeking help. So, will Azusa be able to be relaxed and live in ease again?


11. The Dungeon of the Black Company

Best New Isekai Anime 2021

It has been a while since I’ve seen an excellent isekai anime and this brand new 2021 tv show really stands out. The basic plot is that the MC can’t control the power or anything else in this world either and has to find a way to stay alive.

Kinji lacks any work ethic and finds himself lazy and unmotivated in modern society. One day, he’s suddenly whisked away to another world- not a so good fantasy where he’s welcomed with open arms, but a harsh reality where everything is against him.

In this fantasy world, he finds himself doing a terrible and enslaving job, and he is at the mercy of the evil company while learning what it means to be a hard worker.”


10. Combatants will be dispatched

Best New Isekai Anime 2021

Kisaragi Corporation has been doing really well for themselves in their expansion efforts. Now, They want to bring in new planets but need somebody to scout them out, which is why they chose their agent Six.

On the new planet, Six and his partner were sent to spy on the people and prepare for the takedown by Kisaragi.

Combatants Will Be Dispatched is a 2021 anime mainly focusing on comedy, while It handles the fantasy and isekai genre with a light-hearted tone and implements some good themes found in Science Fiction TV shows.


9. Seijo no Maryoku wa Bannou Desu

Best New Isekai Anime 2021

Sei is 20 years old girl who got summoned to the netherworld. There, She works hard and eventually longs for ease from her harsh life in the netherworld.

One night, she ended up staying late and got tired, so when she went home from her work, it was dark and gloomy. When she walked in the door, a bright and warm light enveloped her. Suddenly a higher power transported her and another high school girl to another world.

The prince called them because he needed their help. Then, He had given them a tough set of tasks.

Unfortunately, she wasn’t labeled as a saint. Sei felt neglected and unwanted. It hurt that they perceived her as an insignificant person, while she was a dedicated workaholic. So she decided to leave the place.


8. Seirei Gensouki

seirei gensouki

This is a very rare happening story in this isekai anime of 2021. Haruto Amakawa, a college student from Tokyo dies in an accident and wakes up in a new world as a young boy named Rio.

Haruto’s thoughts & memories are being merged with those of Rio, and now also has magical abilities.

Rio is a boy living in the slums who wants revenge for his mother who was murdered in front of him when he was five years old. Earth and another world.

Now, Two people with completely different backgrounds and values. will soon after, rescue a kidnapped princess.

As a Reward, The King grants Rio an opportunity to study at a prestigious academy. He is excited and believes this will be the new chapter for his life. However, it does not go as planned and he struggles in life at the prestigious academy surrounded by nobles and those of the upper class.


7. How A Realist Hero Rebuilt The Kingdom

realist hero

This isekai anime of 2021 really Is A Change Of Pace From Combat-Focused Series,

After his grandfather’s death, 19-year-old Kazuya Souma was left all alone and had no one to call family.

He suddenly finds himself transported to the Elfrieden Kingdom, a small ailing country in another world. Now as a hero, They need his help to “save” it from the demon army.

Kazuya is not happy that he’s been put to work as a tribute so he joins the kingdom in order to improve its economy, which has been declining. He does this by implementing administrative reforms.

Kazuya as a king sets out to assemble a group of talented citizens and quickly learns that he must successfully overcome bureaucratic battles in order to rebuild his country.


6. So I’m a Spider, So What?

Best New Isekai Anime 2021

Known in Japanese as Kumo Desu Ga, Nanika? this is an isekai anime tv series of 2021 that you will get hooked to. With a top notch animation style the story follows students going on with their school life as usual until something unusual happened and most of them drop dead while some others finds themselves reincarnated into a fantasy world as nobles, uperclass people, and princes.

Except for an unlucky girl, who is reincarnated into the body and persona of a spider. She feels the struggles of her dire situation. While exploring her new form, she finds that there are rules to govern what she can and cannot do. The limitations of everything in this world are also similar to those of an RPG.

She is trying to hunt prey and defeat monsters and level up in order to evolve into a stronger being with time. This gives her hope that one day she’ll get rewarded for a better life.


5. Tsukimichi: Moonlit Fantasy

Isekai Anime 2021

This all-new isekai anime of 2021 depicts the story is about Makoto Misumi, an ordinary high school boy gets transferred to an alternate world. However, the goddess of that world quickly took a dislike to his face and stripped him of his title as “The Brave Warrior of Existence.” To add insult to injury, she also banished him out of sight from the rest of society.

Although of all these issues, Makoto starts enjoying his otherworldly ventures, meeting all sorts of other non-human species, and improving his magical powers and combat skills.

Now our forsaken boy is trying to adapt to this world, dealing with sudden encounters, and fighting off enemies.


4. Mushoku Tensei: Jobless Reincarnation

isekai animes 2021

Another top isekai anime of 2021 is Maushoku Tensei that portrays a story of a shut-in 34-year-old, who despite all that he has endured from bullying, scorning, and oppression, at the end he did something meaningful in his life before being run over by a speeding truck and dies.

Raborn as Rudeus Greyrat, a baby in another world, begins living an exciting new life.

In Rudeus’ second life in the new world, he tries to make the most of his new opportunity while conquering his traumatic past. All while he may find love that he sought in his old life.


3. That Time I Got Reincarnated as a Slime Season 2

New Isekai Anime 2021

In 2021, we have the chance to enjoy the second season of Tensei shitara Slime Datta Ken.

the story follows Satoru, who has never been in a relationship with a girl and does not even know what one looks like. While taking a break from work, he meets his colleagues. Just as they start talking, someone approaches with a knife, Satoru tries to help and gets stabbed too!

When Satoru regains consciousness, he discovers that he died and now he has reincarnated as a slime in a new fantasy world.

“So, that’s basically what happens to Rimuru, he gets stronger and accumulates magic power, and new skills. Instead of remaining bound to his past, Rimuru decided to venture and enjoy the new life as a slime.


2. Re:Zero kara Hajimeru Isekai Seikatsu 2nd Season Part 2
rezero season 2
After Otto compelling speech, the protagonist Subaru solemnly swears he will succeed in saving everyone he can. The first step to achieving this goal is helping Emilia with the work through her past she’s struggling with.

However, it will be difficult for Emilia to trust anyone even if Subaru is her loyal “knight.” as she feels that All the others have deceived her.

Re:Zero is one of the best isekai anime of all time, and in this 2021 sequel, the show presents a culmination of Subaru’s experiences in the Sanctuary and the people therein, as well as unwillingness to give up hope on saving them.


1. Link Click

Best New Isekai Anime 2021

There’s a lot of genres that are popular in anime and manga. They can be action-packed like dragon ball z, contain mystery like fullmetal alchemist, and even some that offer the concept of horror, and survival like Link Click, which is a perfect new anime for fans who like new unique stories.

The synopsis follows the main characters Cheng Xiaoshi and Lu Guang, who are bestowed with superpowers to enter their clientele’s pictures.

These two are hard-workers who take their job seriously at “Time Photo Studio,” a small photography shop set in the backdrop of a modern metropolis.

Each job may be dangerous, but for them fulfilling orders is always important. Whether big or small, each task must be accomplished without hesitation!

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