Mohsin Lag 
Welcome to this list of the best anime TV shows with powerful female characters! There are plenty of cool, strong, and overpowered anime girls out there. People who believe they are only side characters need to rethink their perspective. As long as you’ve got a good idea of what a good anime series has to offer, you’ll find that there are so many OP anime girls who greatly improve the quality and novelty of the series.
Anime has introduced us to a lot of mighty female protagonists, and yeah, I’m very curious!
So, what are some of the best anime shows where the lead protagonists are overpowered girls that you should not mess with?”
22. Bofuri
Kicking off the list of the best anime with an op female mc with Bofuri. Produced by Silver Link, and spans genres of action, adventure, and fantasy, this is an anime story about Kaede Honjou, who after visiting her friend, she reluctantly agrees to try New World Online: a very popular VRMMO played by thousands of people across Japan.
Named Maple in the game, she sets out on her isekai journey. Maple is a complete beginner to this type of game and desires not to get hurt. Her character has a high defense with no focus on anything else, and she can’t move quickly or hit hard. Her high defense doesn’t result in disaster because she gets some powerful skills.
Maple becomes so overpowered, and she is a girl who quickly becomes one of the best players in it and even progresses very quickly. She also starts to gain a reputation as a player with acclaim – one of the best on the whole server.
Kaede progressively improves throughout her journey. The more she learns, the more she gets to explore and enjoy the game even more. She meets new friends, who help her complete different tasks along the way. Otherwise, Kaede might develop some weird new skills as well!
21. Izetta: The Last Witch
Izetta the last witch is among the best magic anime with a powerful heroine. The story of this military series takes place in the wake of war, and by defending her country, the protagonist puts her life on the line. In short, this anime is about a small country fighting Germany with magic. That’s all. But if you want a piece of more detailed information… let’s follow this epic tale of Izetta, the last remaining witch in this fantasy world, who is a 15-year-old girl on a journey to protect her country and its princess.
20. Moribito: Guardian Of The Spirit
- Episodes: 26
- Studios: Production I.G
- Genres: Action, Adventure, Fantasy, Historical
Moribito by Production I.G is an interesting anime show with an overpowered female lead to watch. With its slow pace and unfolding investigation into the life of Balsa, with flashbacks to her past, you will be hooked on watching it to see what happens next.
Although this is a fantasy action drama that is meant to be serious, there are some genuinely funny moments. This is beautiful series that follows one pretty and powerful anime woman as she embarks on a journey to protect Chagum, exploring life and its beauty through nature, family, and the bonds formed between strangers.
19. Ergo Proxy
I have watched Ergo Proxy and would say that it is one of the most enjoyable dark anime shows with an overpowered female ptotagonist I have ever seen.
The anime is psycologyical tale that comes with complex and unknown things that can be very difficult to follow because of the gaps in between explaining the story. However, as soon as you finish watching the series, you will have a better understanding and no doubts left in your mind.
The plot is set after an apocalypse took place, where humans started to coexist with robots in harmony. In this post-apocalyptic world where no one knew what was to come, everything was left a mystery. I don’t want to talk too much about what Ergo Proxy is trying to say. If you enjoy dark anime stories set in this kind of dystopian setting, then you’ll probably like how it looks.
18. Blood-C
Blood C is horror supernatural anime that centers around a school girl called Saya who has a daytime life of peace and is an op demon slaying monster at night. Armed with a ceremonial sword inherited from her venerated father, she kills every monster who may try to destroy the village and threatens its peace.
But Saya’s reality is tested soon after when she discovers from the monsters that there was a broken promise in their contract. Then, unexpectedly, a strange dog appears and asks her to whom she promised to protect the village; it is curious as to what will happen if she were to break that promise. Unable to control what she sees, Saya desperately searches for answers. But nothing seems to make sense in the town.
17. Noir
Sometimes, people struggle to find their identity. Noir is an anime where two overpowered girls are assassins! one with amnesia and the other with a troubled past, struggle together as they are trying to find out their past, and their place in their respective lives and the world around them.
Though Noir has a plot that is very similar to some other series, it somehow manages to make it more interesting. Once the story picked up, I was glued to the screen and on the edge of my seat until the end.
16. Slayers
Next up among the best adventure fantasy anime with a strong female main character, we have Slayers which is good series that follows the adventures of the renowned sorceress Lina Inverse and her ‘protector’ Gourry Gabriev as they travel the land in search of anything that can get the treasure.
The show is set in the world of Dungeons and Dragons. It includes familiar aspects such as quests and magical items and overpowered anime girls. The story will feel like a game to gamers, making it easy for them to connect with it. Even if you’re not a fan of these kinds of games, the story is compelling and captivating, and you can appreciate the action-packed drama that unfolds in each episode.
15. Rosario to Vampire
This is a good ecchi action school anime with strong vampire girl as the main character. Set at one of the most diverse schools in Japan, Youkai Academy specializes in educating monsters and humans alike. There is an epic story going on in this school being anything other than perfect.
Those unordinary students attend class in their normal human form, and take classes like literature, gym, foreign language, and mathematics However, at Youkai Academy there is one rule – all humans found on school grounds are to be executed immediately!
Tsukune Aono is a teenager who is struggling with his grades which prevents him from attending any school. His parents enrolled him in Youkai Academy as their final option. Immediately upon entry, Tsukune was approached by a girl called Moka. She seemed nice and friendly, but he does not realize that beneath her beauty lies a menacing vampire.
14. The Promised Neverland
The Promised Neverland is a mystery suspenful anime with a smart frmale main character you will root for. Set in Grace Field House, a place for orphans, where children live together in a family environment. They care for one another and play in the same way as siblings. Isabella is their Mama who takes care of these kids. Although the children are required to take tests daily, they are free to spend their time as they see fit; usually playing outside, as long as they do not venture far away from the orphanage.
The twist will kick off, when a child is adopted and sent to live with a new family, never to be heard from or seen again. The three oldest siblings start having their suspicions about what is really happening at the orphanage. They’re ready to discover the twisted nature of their beloved Mama and all that awaits the children living at Grace Field, which includes their mysterious fate. The series has one of the most powerfu and smartest anime girls of all time, her name is Emma and you will fall in love with her from first sight.
13. Shakugan No Shana
- Episodes: 72, Three seasons
- Studios: J.C.Staff
- Genres: Action, Drama, Fantasy, Romance, Supernatural, Mahou Shoujo, School
Shakugan No Shana is a magical girl fantasy anime with an op female mc. The story starts out at an exciting point and I was really looking forward to it. It’s about a normal boy whose life gets turned upside down after a bizarre experience, and he no longer exists as he was before. Now he may even fade away and get forgotten by everyone. Meanwhile, he will discover mysterious new powers of his own and gets mixed up in the world of magic, and battle alongside the fierce red-haired girl, Shana.
12. Canaan
Made by P.A Works, Canaan is a mafia anime that follows the story of Maria, a photographer, and her friend who heads to China on investigative work. Maria quickly finds herself in the middle of a fierce gunfight between some sort of gang. Therefore, an op girl named Cannan jumps in to protect her childhood friend and help her escape the crossfire.
This anime features a fierce fight between two overpowered girls and is perfect for anyone who likes an action-packed adventure story with some moments of comedy. The truth is, short anime series like Canaan can be a bit unpredictable, but you’ll be glad to know this one is worth the watch.
11. The Future Diary
Future Diary is a horror action anime that focuses on the lonely high school student, Yukiteru Amano, who spends his days writing a diary on his cellphone while conversing with his two seemingly imaginary friends Deus Ex Machina, who is the lord of time and space, and Murmur, the lord’s servant.
Revealing himself to be an actual entity, Deus grants Yukiteru a “Random Diary,” which shows highly descriptive entries based on the future and forces him into a bloody battle royale with 11 other holders of similarly powerful future diaries.
With the last person standing designated as the new lord of time and space, Yukiteru must find and kill the other 11 in order to survive. He reluctantly teams up with his obsessive stalker Yuno Gasai (who also possesses such a diary), and she takes it upon herself to ensure his safety. But there’s more to the girl than meets the eye, as she might have other plans for her unrequited love… If you are looking for a good anime that boasts powerful girls, then Future Diary is one is the best choices!
10. Claymore
Madhouse’s Claymore is a supernatural anime series that features many overpowered demonic anime girls who are actually known as Claymores. The story kicks off when a shapeshifting demon with a thirst for human flesh, known as “youma,” arrives in Raki’s village, a lone woman with silver eyes walks into town with only a sword upon her back. She is a “Claymore,” a being manufactured as half-human and half-youma, for the express purpose of exterminating these monsters.
After Raki’s family is killed, a Claymore girl saves his life, but he is subsequently banished from his home. With nowhere else to go, Raki finds Claymore, known as Clare, and decides to follow her on her journey.
As the pair travel from town to town, defeating youma along the way, more about Clare’s organization and her fellow warriors comes to light. With every town cleansed and every demon destroyed, they come closer to the youma on which Clare has sought vengeance ever since she chose to become a Claymore.
9. Witch Craft Works
Witch Craft Works by J.C.Staff is an action fantasy anime with a beautiful powerful magical girl. The story focuses on Honoka Takamiya, who was perfectly happy with his completely average and normal life. His primary problem in life was the fact that he shared a school with the school’s “Princess,” Ayaka Kagari.
Both girls and boys fawn over her which makes Honoka’s life difficult since he rides the same bus as her in the morning and sits next to her in class.
What’s worse is that if he even idly interacts with her, her fan club takes him out back and beats him up! One day while taking out the trash he looks up to see a school building falling on top of him! He is saved at the very last moment by the very same beautiful girl, Ayaka, whom he’s never even had a full conversation with.
She finally speaks to him, revealing that she’s been protecting him in secret, but now that someone is attacking him directly she no longer needs to do it covertly. It turns out that Ayaka is a fire witch and there are other witches in the world who want to capture Honoka and use him for the power that he possesses inside of him.
8. Yona of The Dawn
Well, Yona of The Dawn is one of the most popular romance action animes of all time due to its unique storyline, and the transformation of Princess Yona, who used to be an innocent girl but will turn into a badass strong girl.
She used to live a peaceful life, and her only worries were if her hair color would fit with the rest of her outfit and whether or not she’ll get to marry her childhood crush- Soo-won.
However, her father forbade their marriage and she never understood why. Suddenly, Soo-Won bursts into the room and impales the king with his sword.
Once in love with Soo Won, who killed the king and take her kingdom, Yona is heartbroken and therefore begins to live as a fugitive, but she’s accompanied by one of the king’s most trusted knights: Haku. Yona, with the help of her guardian and other friends she meets along the way, will turn from a spoiled girl to an overpowered female character in order to get her revenge!
7. Darling in the Franxx
Coming up, among the best anime with overpowered girls is Darling in the Franxxx. This is a mecha action romance anime set in a futuristic world where people have been driven to endangerment by giant beasts. Living in ruin, humans decide to form a strike force in order to destroy the monsters and save the world…
This force consists of pilots produced inside the Plantation, also known as the “birdcage.” The main enemies they’re up against are giant creatures called “Kyouryuu`, and their weapons are Franxx robots designed to combat them. It is not that easy to pilot a Franxx! The story mainly focuses on a boy named Hiro, a prodigy. However, he has fallen to become a pilot, and his existence seems unnecessary. Not piloting a Franxx is the same as ceasing to exist.
A mysterious girl, Zero Two, appears before him. She will change his life. Zero Two invites Hiro to pilot the Franxxx with her, and the duo easily defeats the Klaxosaur in the ensuing fight. Now, Hiro has been given a chance at redemption for his past failures, but at what cost?
6. Puella Magi Madoka Magica
Puella Magi Madoka Magica is a famous anime series that follows a group of overpowered magical girls as they encounter a series of dark and unusual events. The story can be quite confusing at first, but it quickly unravels into a story full of hope, despair, and the importance of friendship.
This popular magic with an op female main character chronicles an adventurous tale in a magical world where there are some dark and evil witches. One girl is offered a wish in exchange for a commitment to battle these bad beings.
5. Medaka Box
Next up, we have Medaka Box, a really wonderful anime with a powerful female lead that no one can mess with!
Medaka Kurokami is the new council president, she institutes her plan for making a suggestion box where students can write their issues that need to be solved by adding them to the box.
At first, she was expecting small problems like rescuing lost puppies and giving advice. However, what she and her best friend Zenkichi stumble upon are the first hints of a hidden secret.
When Medaka and her teammates found themselves in the middle of a dangerous game, they also discovered more about their own strengths and abilities. Therefore, things get really out of control!
4. Kill La Kill
It’s not fair to discuss anime series featuring overpowering girls without referencing Kill la Kill. The show revolves around Satsuki Kiryūin, the president of the student council, and her loyal subordinates known as the “Elite Four,” who hold dominion over Honnōji Academy. Thanks to their unique uniforms, they exercise absolute control over the institution, harnessing superhuman capabilities through these outfits.
The transfer student Ryuko Matoi, is a girl seeking to find her father’s killer. She ends up coming to Hannouji and challenges the Elite Four to a fight that quickly consumes the school. The outcome of the battle will make Satsuki recognizes Ryuko’s scissor-shaped sword, she wonders if this is just a coincidence or if it’s fate!
3. Black Lagoon
Black Lagoon by Madhouse Studio, stands as one of the top anime featuring overpowering and formidable girls. The series encompasses themes such as Mafia, Dark World, Friendship, and more. In this compelling dark action anime, the main character undergoes a transformation from a businessman to a hostage. His initial intention was a business meeting, but he finds himself abducted by Black Lagoon, a merciless mercenary group.
After waiting and waiting, it seems that no one will come to rescue him, so instead, he decides to join the mafia group. There are so many powerful female characters in this anime, and it is definitely one that many fans have and will enjoy. Black Lagoon anime focus on the depths of human morality and virtue.
2. Elfen Lied
Moving on to the next best anime with and overpowered female main character we have Elfen Lied. This is a psychologial horror anime that features one of the craziest girls of all time.
The show follows Two students who meet a likely harmless girl named “Lucy”, Lucy is a special breed of human a.k.a “Diclonius,”.
She is a victim of scientific experimentation by the government. As a result, she is born with a short pair of horns and invisible telekinetic hands.
However, once circumstances give her an opportunity to escape, Lucy unleashes a torrent of bloodshed as she escapes her captors. She was injured during her breakout and is unaware that she’s actually a mutant serial killer with a split personality.
1. Akame ga Kill!
Produced by White Fox Studio, Akame Ga Kill stands as a fantasy action anime showcasing a plethora of exceptionally strong female protagonists. These formidable girls possess a level of power on par with the most renowned and potent male characters in history. With the ability to effortlessly vanquish their adversaries and triumph over even the most influential opponents, these powerful heroines leave a trail of defeated foes in their wake.
The story chronicles the Night Raid, a covert assassination branch of the Revolutionary Army. The country is now in ruins. Without a strong and benevolent leader, the whole nation is left to drown in poverty, strife, and despair.
Though the Night Raid members are all professional killers, they understand that taking lives is a bad thing and that they will likely face retribution as they mercilessly eliminate anyone who stands in the revolution’s way.
This strong band of assassins’ newest member is Tatsumi, a naïve boy from a remote village who had embarked on a journey to help his impoverished hometown and was won over by not only Night Raid’s ideals, but also their resolve.
