18 Best Demon-Human Relationship in Anime To Watch

18 Anime Featuring Demon-Human Relationships

Anime fans are used to ordinary romance stories but if you’re looking for something different, demon-human relationships is a theme that might be the way to go. These shows are about supernatural beings and humans and gives a fresh and warm take on love. Although these relationships are unconventional they are often super awesome. With genres like supernatural, fantasy or isekai mixed in these shows, it really brings a new spin to the romance genre. As of 2024, we’ve updated this list to include the latest demon-human relationship anime so you’ll find both old and new series to watch.

Ready for anime love stories that goes beyond the ordinary? Check these out!

18. Otome Youkai Zakuro

• Studio: J.C.Staff
• Genres: Historical, Romance, Supernatural
• Episodes: 13
• Release Date: October 5, 2010

Set in a period when Japan is modernizing, Otome Youkai Zakuro tells the story of humans and spirits attempting to coexist. Zakuro, a spirited half-demon girl, teams up with Lieutenant Kei Agemaki to solve supernatural mysteries. Initially wary of humans, Zakuro forms a connection with Kei as they work together, learning to trust and understand one another. Otome Yukai Zakuro is good anime that follows the relationship between a half-demon girl with a human boy, as their love grows through shared challenges and overcoming prejudice and fear. 

17. Yuushibu: I Couldn’t Become a Hero, So I Reluctantly Decided to Get a Job

• Studio: Asread
• Genres: Comedy, Romance, Fantasy
• Episodes: 12
• Release Date: October 5, 2013

Yuushibu is an anime that follows Raul, whose dream is to become a hero, but it ends when the Demon Lord is defeated. Now working at a magic shop, he meets Phino, the cheerful daughter of the Demon Lord. Despite their species differences, Raul and Phino develop a charming relationship as they deals with their new lives. Phino’s innocence and Raul’s reluctance create a fusion of humor and heartwarming moments. 

16. The Foolish Angel Dances with the Devil

• Studio: Children’s Playground Entertainment
• Genres: Romantic Comedy, Supernatural
• Episodes: 12
• Release Date: January 9, 2024

As we update our list, we’ve come across a new 2024 anime that spans the demon-human relationship theme called The Foolish Angel Dances with the Devil. In a world where Heaven and Hell are at odds, demon Masatora Akutsu infiltrates the human realm to find allies. There, he meets Lily Amane, a stunning girl who turns out to be an angel devoted to hunting demons. Despite being on opposite sides, Masatora and Lily form a complicated bond filled with humor and budding romance. This series offers a fresh take on the hardships of love between beings from vastly different worlds.

15. Inu x Boku SS

• Studio: David Production
• Genres: Comedy, Romance, Supernatural
• Episodes: 13
• Release Date: January 12, 2012

Ririchiyo Shirakiin moves into a high-security mansion where each resident is paired with a supernatural Secret Service agent. Her assigned agent, Soushi Miketsukami, is a fox spirit devoted to her. Initially hesitant to accept his care, Ririchiyo slowly opens up as Soushi proves his loyalty and affection. Their relationship evolves into a sweet and supportive romance. Inu x Boku is a an anime with supernatural aspects and heartfelt moments, making the mentioned relationship between a human and a spirit both endearing and memorable. 

14. My Oni Girl

• Studio: Studio Colorido
• Genres: Fantasy, Romance
• Epsiodes: Movie
• Release Date: May 24, 2024

Yatsuse Hiiragi, a high school student, encounters Tsumugi, an Oni (demon) girl searching for her mother in the human world. Their journey together leads to a deepening bond, exploring themes of acceptance and love that transcend their different natures. My Oni Girl is an anime movie of 2024 that offers a heartfelt story of connection between human and demon.

13. The Demon Sword Master of Excalibur Academy 

• Studio: Passione
• Genres: Action, Fantasy, Romance
• Episodes: 12
• Release Date: October 3, 2023

Next, and one of the newest addition to the list of demon-human romance anime is The Demon Sword Master of Excalibur Academy, a 2023 release. After waking from a thousand-year slumber, the Dark Lord Leonis finds himself reincarnated in the body of a ten-year-old boy. He joins Excalibur Academy, where he meets Riselia, a brave young girl fighting mysterious enemies. As Leonis helps Riselia in her battles, their connection gets stronger, bringing elements of romance into their supernatural adventures.

12. Rosario + Vampire

• Studio: Gonzo
• Genres: Comedy, Romance, Supernatural
• Episodes: 26 (2 seasons)
• Release Date: January 3, 2008

Tsukune Aono, a human boy, stumbles into Youkai Academy, a school filled with monsters who are forbidden to harm humans. There, he meets Moka Akashiya, a vampire girl with a dual personality. While Moka’s kind side draws him in, her vampiric nature adds tension to their relationship. Tsukune decides to stay at the academy to be with Moka, despite the risks. Their romantic relationship is full of funny moments and epic encounters, showcasing the results of love between a human and a monster. 

11.  Maoyuu Maou Yuusha

• Studio: Arms
• Genres: Adventure, Romance, Fantasy
• Episodes: 12
• Release Date: January 5, 2013

Next we have Maoyuu Maou Yuusha, where a hero confronts the Demon Queen, expecting a climactic battle. Instead, she persuades him to work with her to end the war peacefully. As they collaborate on strategies to unite humans and demons, their respect for each other deepens into love. Their partnership is a testament to how mutual understanding can overcome enmity. If you are looking for a romance anime with social commentary, then this is the best one that features a refreshing view on those kind of demon x human relationships defying the norms. 

10. Hataraku Maou-sama! 

• Studio: White Fox
• Genres: Comedy, Romance, Fantasy
• Episodes: 13
• Release Date: April 4, 2013

Hataraku Maou-sama! is about Sadao, a demon king who after being defeated by Hero Emilia is forced to drift to modern day Tokyo. In this new world Sadao’s skills as a conqueror are useless and he has to work as a freeter to make ends meet. The anime is about Sadao’s struggles to adapt to life in the human world and his relationship with Emilia. Their rivalry turns into an unlikely friendship and with hints of romance added to the mix. The series is a comedy isekai with romance between demons and humans.

9. Shiki 

• Studio: Daume
• Genres: Mystery, Supernatural, Thriller
• Episodes: 22
• Release Date: July 8, 2010

Set in the village of Sotoba, where the unexpected death of a young girl named Megumi Shimizu marks the beginning of a terrifying epidemic. As the hot summer turns into a season of blood and terror, a young doctor named Toshio Ozaki begins to question the nature of the disease and must abandon his humanity to uncover the truth. Natsuno Yuuki, an antisocial youth from the city, is also affected by Megumi’s death and grapples with the pain of friendship in the face of tragedy. Together, Toshio and Natsuno form an unlikely partnership to save Sotoba from becoming a ghost town of vampires. While the romance is subtle, Shiki is an anime that depicts themes of connection, survival, and relationships between humans and vampires, blurring the lines between humanity and monstrosity. 

8. Dance with Devils 

• Studio: Brain’s Base
• Genres: Supernatural, Romance, Musical
• Episodes: 12
• Release Date: October 7, 2015

Next, we have a sweet romance anime that revolves around a demon-human bond. The story centers on Ritsuka Tachibana, a second-year high school girl living a quiet life in the picturesque town of Shikou Village. Her peaceful days come to an end when she encounters mysterious beings who may be human—or something far more sinister. As Ritsuka uncovers the hidden motives of these enigmatic figures, she is drawn into a world of secrets that challenge her understanding of her identity and reality. The series masterfully depicts themes of love, power, and morality, exploring the fine line between good and evil as Ritsuka finds herself surrounded by alluring demons.

7. Kamisama Hajimemashita 

• Studio: TMS Entertainment
• Genres: Comedy, Romance, Supernatural
• Episodes: 13
• Release Date: October 2, 2012

Kamisama Kiss is a heartwarming anime about a demon-human romantic tale. Produced by TMS Entertainment, the series has 13 episodes. It follows Nanami Momozono, a high school girl who becomes homeless after her father runs away to escape gambling debts. When she saves a man from a dog, he offers her his home, which turns out to be a shrine. To her surprise, Nanami is now the new local deity and must handle her divine duties. Along the way, she meets Tomoe, a grumpy yet charming fox familiar, who reluctantly helps her adjust to her new life.

6. Re: Zero kara Hajimeru Isekai Seikatsu 

• Studio: White Fox
• Genres: Drama, Fantasy, Thriller
• Episodes: 50+
• Release Date: April 4, 2016

Re– Starting Life in Another World is a must-watch anime that combines psychological drama, fantasy, suspense, and demon-human relationship. Produced by studio White Fox, the series follows Subaru Natsuki, a regular teenager who is mysteriously transported to a fantasy world after a trip to a convenience store. Almost immediately, he is attacked by thugs but saved by Satella, a kind girl searching for her stolen insignia. Grateful for her help, Subaru offers to assist her, but their journey takes a dark turn when a mysterious force kills them both. However, Subaru awakens to the same moment he first arrived, reliving the encounter with the thugs. Confused and determined, he begins to unravel the truth about his powers and the strange, dangerous world he’s trapped in.

5. The Ancient Magus’ Bride

• Studio: Wit Studio
• Genres: Fantasy, Supernatural, Romance
• Episodes: 24
• Release Date: October 8, 2017