The first anime siblings that touched my heart were Ace, Sabo, and Luffy from the popular anime and manga series One Piece. Well, their bond was unbelievable, and it really made an impact on every fan. However, they are not the only siblings featured in anime history, because there are so many other brothers and sisters that are just as good as the ones in One Piece. With no further ado, let’s dive deep into the anime world and discover the 23 best anime siblings of all time that you should know about.
23. Lord A and Killer B
The first siblings on our list, are Lord A and Killer B from the Naruto anime and manga series. Lord A uses lightning, while Killer B is a Jinchuriki, which means he has the power of a tailed beast. They are both strong ninjas with distinctive skills. As siblings, they are quite close, and Killer B frequently teases and makes fun of his elder brother. Despite having quite different personalities and skill sets, they genuinely respect and care for one another. They cooperate to defend their town and their fellow ninjas, utilizing one another’s strengths in combat.
22. The Sohma Siblings
The Sohmas are brothers and sisters from the Fruits Basket manga and anime series. These siblings belong to the Sohma family, who are cursed to change into Chinese zodiac animals whenever they receive a hug from a person from the opposing gender. They have a strong affinity as siblings and are constantly there for one another when it counts the most, despite their complicated relationship. Together, they face the hardships posed by their family’s curse while encouraging one another through life’s ups and downs.
21. Kagami and Tsukasa Hiiragi
In the anime series Lucky Star, Kagami, and Tsukasa are depicted as twin siblings who are attending the same high school. Tsukasa is the more easygoing and laid-back one, whereas Kagami is the more studious and serious of the two. Despite their differences, they have a close relationship as sisters and often encourage one another. Along the way, they negotiate high school life while juggling examinations, friendships, and potential romantic partners. They continue to rely on one another for support and strength because of their unbreakable twin link.
20. Taihei Doma and Umaru
One of the cutest anime siblings ever is Umaru and Taihei from the anime series Himouto! Umaru-chan. In the eyes of others, Umaru is a model student, but at home, she behaves selfishly and lazily, spending all of her time playing video games and snacking. Her older brother, Taihei, looks after her and makes an effort to control her. They negotiate life while traveling, having to contend with Umaru’s immaturity and selfishness. Despite their differences, they remain close as siblings and support one another.
19. Hiroomi and Mitsuki Nase
In the anime and manga series Kyoukai no Kanata, there are two beautiful siblings named Hiroomi and Mitsuki Nase. They are members of a family of spiritual warriors and are extraordinarily strong and reliable. The younger sister Mitsuki is still learning how to handle her skills, thus Hiroomi, the older brother, frequently serves as a mentor to her. They have a strong bond and will always be there for each other despite their differences in age. They are prepared to put their lives in danger to safeguard one another and their family, and they always cooperate to get the job done.
18. Maki and Mai
Maki and Mai Zenin from Jujutsu Kaisen are sisters who belong to a powerful sorcerer family in the world of Jujutsu Kaisen. The twin sisters were born as members of the Zenin family. While Maki, who needed special glasses to see curses, was braver than Mai as a child, Mai relied on Maki since she was more scared as a child. However, Mai started to detest her sister for leaving her behind when Maki left the clan to follow her own way and finally came back to take over the role of family leader. The sisters are still at odds, and it is yet unclear how their continuous conflict will turn up.
17. Otae and Shinpachi
The Gintama anime and manga series features the funny siblings Otae and Shinpachi Shimura. Otae, a talented fighter and the manager, and Shinpachi, a member of the Yorozuya, a freelance odd jobs company, work together to run the Snack Smile cafe. They argue frequently and are close, but they also help one another out when things get difficult. They have a close relationship as sister and brother and will support one another through any difficulties they may encounter.
16. Inuyasha and Sesshomaru
Half-brothers Inuyasha and Sesshomaru, who have a tense relationship, are a well-known classic sibling pair in anime history. Sesshomaru, a full demon, is much more powerful than Inuyasha, a half-demon. During their journey, they must traverse their past and eventual destiny as demons. Their brotherly bond is put to the test as they struggle to protect their loved ones, despite their differences and conflicts, and ultimately they support one another.
15. Hikaru and Kaoru Hitachiin
From the anime and manga series Ouran Highschool Host Club, Hikaru and Kaoru Hitachiin are twin brothers. They share an extremely deep bond and nearly identical appearances as identical twins. They frequently appear together and enjoy executing silly jokes and picking on people. However, as they get more active with the school’s host club, their individual personalities and interests start to come out. Kaoru is more reserved and introspective while Hikaru tends to be more competitive and outspoken. They may disagree, but they have a strong brotherly bond and will always support one another.
14. Shigeo and Ritsu Kageyama
The brothers Shigeo and Ritsu Kageyama are from the Mob Psycho 100 manga and anime series. Both of the siblings have psychic abilities, with Ritsu originally being smart but longing for them and Shigeo being an extremely powerful esper who has trouble controlling his emotions. Their relationship deteriorates as the story goes on because Ritsu harbors resentment against Shigeo’s talents. They eventually make up, though, and cooperate to defend their loved ones. They have a strong bond and will go to great lengths to defend one another.
13. Tobirama and Hashirama
Tobirama and Hashirama are the creators of Naruto’s Hidden Leaf Village. They are also brothers who share a special link and a common goal: to make the world a more peaceful place for all shinobi. Tobirama is a brilliant ninja who invented various Jutsu techniques, including the Summoning Jutsu, but Hashirama is renowned for his vast chakra and ability to control tailed beasts. Regardless of their disputes, they always had each other’s backs and worked together to attain their objectives.
12. Satsuki and Ryuko Kiryuin
Half-sisters Satsuki and Ryuko Kiryuin appear in the Kill La Kill anime and manga series. Satsuki, the head of Honnouji Academy’s influential student council, and Ryuko, a transfer student out for vengeance against the school, initially find themselves on opposite sides of a confrontation. They are both incredibly strong and determined despite their differences. Their relationship becomes increasingly complicated as the series goes on, and they ultimately set aside their differences to combat a shared foe. They learn that they are sisters who have a close relationship and that their love for one another is more essential than any rivalry or conflict.
11. Elfman, Lisanna, and Mirajane Strauss
From Fairy Tail, Elfman, Lisanna, and Mirajane Strauss are just one of the top anime siblings of all time. They all have amazing magical skills and are Fairy Tail’s guild members. While Lisanna initially lacks magical prowess but later acquires the ability to change into animals through magic, Elfman and Mirajane are strong magi. They have a close relationship as siblings and support one another no matter what, even through the most trying times. They had a complicated past; Lisanna is thought to have passed away, which caused Elfman’s emotional collapse and Mirajane’s personality change. However, they became happier to be reunited as a family when it is revealed that Lisanna is still alive. With their mutual affection for one another and their might as a trio in battle, they continue to fight together under the guidance of their guild.
10. Rin and Yukio Okumura
Throughout the anime series Blue Exorcist, we follow the story of the siblings’ Rin and Yukio, who grew up in a world where exorcists and demons cohabit. Yukio is an exorcist, while Rin is a demon. Despite their disagreements, they have a strong brotherly bond and work together to keep the planet safe from demons. Yukio mentors Rin and teaches him how to harness his demonic talents. Rin, for his part, uses his abilities to aid his brother and combat evil. They confront several hardships and battles along the way, yet their relationship as brothers remains unbroken.
9. Sora and Shiro
No Game No Life’s Sora and Shiro are two siblings that are invincible at gaming. In a world where everything is decided by games, they are a force to be reckoned with, and their abilities and intelligence are unparalleled. They’re known as the “Blank” because of their unbeaten streak. They enter a new world together, where they must conquer other races and become rulers. Throughout their voyage, they experience several problems yet rely on one another to overcome them. Their sibling relationship is unshakable, and they rely on their abilities and wits to protect each other and their loved ones.
8. Jonathan and Dio
In Jojo’s Bizarre Adventure anime series, Jonathan and Dio are stepbrothers who have a complex relationship. Dio is a cunning and nasty character who has a grudge towards Jonathan and his family. He attempts to take over Jonathan’s life and fortune, sparking a fierce rivalry between the two. Despite the stress, Jonathan maintains his integrity and battles Dio’s plots to protect his loved ones.
7. Tatsuya and Miyuki Shiba
Tatsuya and Miyuki are siblings featured in the anime series Mahouka Koukou No Rettoussei. They attend the same magic school, where Tatsuya is known as the “irregular” because of his unusual abilities, while Miyuki is a high-ranked student. Despite their differences, they have a strong sibling bond and work together to keep their school safe. Tatsuya uses his special talents to protect Miyuki and their classmates, while Miyuki supports and assists him in any way she can. Their bond as siblings is solid, and sometimes they look like adoring each other in a romantic way, which is really weird.
6. Shoto and Toya Todoroki
My Hero Academia’s Shoto and Toya are brothers who have had a difficult relationship with their father, a powerful hero who abused them in his desire to create the perfect hero. My Hero Academia’s main character, Shoto, is the result of his father’s experiment and bears the wounds of his torture. Toya, the eldest son, was considered a failure and was rejected by his father. Throughout their quest, they struggle with their emotions and their eventual fate as grown-ups while navigating their intricate family past.
5. Johan and Nina Liebert
From the classic anime and manga series Monster, Johan and Nina Liebert are twins. With Johan being a cunning and out of control serial killer and Nina being a sympathetic and loving psychiatrist, their connection is confusing and heartbreaking. As the series goes on, their previous trauma and family secrets are revealed, forcing them to face the truth about their pasts and their relationships with one another. They are deeply bonded as siblings despite their differences, and their love for one another is ultimately what motivates them to face their past and work for a better future.
4. Tanjiro and Nezuko Kamado
Tanjiro and Nezuko are two of the greatest anime siblings, with a special bond as demon hunters. In the series Demon Slayer, we follow their story, as Nezuko is turned into a demon after her family is slain by demons, and Tanjiro sets out on a trip to find a solution for her illness. Throughout their trip, they must deal with their own emotions as well as their eventual fate as demon hunters. Their sibling relationship is unshakeable, and they continue to assist one another in their mission to safeguard humanity from the demon threat.
3. Luffy, Ace, and Sabo
In One Piece, Luffy, Ace, and Sabo are three brothers who have a deep friendship and a love of adventure. Luffy is the captain of the Straw Hat Pirates, and Ace and Sabo are both formidable pirates. They were kids who were raised in the same home under the care of Dadan. They will later swear to become pirates together when they grew up. Despite obstacles and failures, they never gave up on their dream and remained supportive of one another throughout their journey.
2. Itachi and Sasuke Uchiha
Naruto’s Itachi and Sasuke are brothers from the Uchiha clan, a powerful ninja clan in the Naruto universe. Itachi, the older brother, was a member of the Uchiha clan until betraying them and joining the opposing village to protect his younger brother. Sasuke, who was still a child at the time, was scarred by the event and retains a strong animosity toward his brother. Throughout their story, we see them as they fight each other, negotiate their tumultuous past, grappling with their emotions and their ultimate fate as Uchiha clan members.
1. Edward and Alphonse Elric
Wrapping up our list of the best anime siblings of all time with Edward and Alphonse, who are the primary characters of the Fullmetal Alchemist series. As brothers, they have an unbreakable relationship and are motivated to redeem the wrongs of their past. They experience disastrous repercussions after attempting to resurrect their deceased mother through alchemy. Alphonse loses his entire body, while Edward loses his left leg. Edward sacrifices his right arm to bind Alphonse’s soul to a set of armor in a desperate bid to bring his brother’s body back. The two set out on a trip to find the Philosopher’s Stone in the hopes of using it to reclaim their original selves. They endure several challenges along the way, yet they continue to rely on one another for strength and support.